mYRIAD mATRIX

Myriad Matrix™ has been designed for surgical soft tissue reconstruction and complex wounds.

Myriad Matrix™ combines layers of AROA ECM™ extracellular matrix (ECM) with engineered perforations to facilitate rapid cell infiltration and migration in a wide range of anatomical sites and individual situations.

Myriad Matrix™ is strong, soft, drapable, and conforming
Myriad Matrix™ rehydrates quickly and is easy to cut, suture, or staple
Myriad Matrix™ helps to achieve surgical mastery in routine and more challenging dermal reconstructions and complex wounds

Indications

Myriad Matrix™ is indicated for implantation to reinforce soft tissue where weakness exists in patients requiring soft tissue repair or reinforcement in plastic and reconstructive surgery or for management of the following wounds:

Partial- and full-thickness wounds
Pressure ulcers
Venous ulcers
Diabetic ulcers
Chronic vascular ulcers
Tunneled/

Partial- and full-thickness wounds
Pressure ulcers
Venous ulcers
Diabetic ulcers
Chronic vascular ulcers
Tunneled/undermined wounds
Surgical wounds (donor sites, grafts, post Moh’s surgery, post laser surgery, podiatric, wound dehiscence)
Trauma wounds (abrasions, lacerations, second-degree burns, and skin tears)
Draining wounds

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How It Works

Myriad Matrix™ devices contain the natural porous structure of AROA ECM™, engineered with interstitial perforations to enable cell infiltration to facilitate rapid healing.

Fast absorption of blood & cells accelerates host cell infiltration

The rapid absorption of blood and blood components forms a reservoir of biologically important cells and cell components to help kick-start the tissue repair process.(1-4) Fibroblast, endothelial and immune cells infiltrate the entire matrix, build new tissue and over time Myriad Matrix™ is completely remodeled by the patient’s own tissue.(3, 4)

Delivers biology known to be important in healing

Myriad Matrix™ retains the authentic structure and complexity of natural tissue ECM and provides biological cues to aid the repair process. (5) Myriad Matrix™ contains more than 150 ECM proteins, including collagen and other secondary molecules that exist in tissue and aid the healing process. (6)

Contains residual vascular channels

Angioconduction is the structural effect of vascular channels on endothelial cells to support blood vessel development. Myriad Matrix™ promotes angioconduction via the residual vascular channels within the Aroa ECM™ source biomaterial, helping to facilitate the rapid establishment of a dense capillary network. (7, 8)

1. G. A. Bohn and A. E. Chaffin: Extracellular matrix graft for reconstruction over exposed structures: a pilot case series. J Wound Care, 29(12), 742-749 (2020) doi:10.12968/jowc.2020.29.12.742 2. A. E. Chaffin and M. C. Buckley: Extracellular matrix graft for the surgical management of Hurley stage III hidradenitis suppurativa: a pilot case series. J Wound Care, 29(11), 624-630 (2020) doi:10.12968/jowc.2020.29.11.624 3. S. M. Irvine, J. Cayzer, E. M. Todd, S. Lun, E. W. Floden, L. Negron, J. N. Fisher, S. G. Dempsey, A. Alexander, M. C. Hill, A. O’Rouke, S. P. Gunningham, C. Knight, P. F. Davis, B. R. Ward and B. C. H. May: Quantification of in vitro and in vivo angiogenesis stimulated by ovine forestomach matrix biomaterial. Biomaterials, 32(27), 6351-61 (2011) doi:l10.1016/j.biomaterials.2011.05.040 4. N. Overbeck, G. M. Nagvajara, S. Ferzoco, B. C. H. May, A. Beierschmitt and S. Qi: In-vivo evaluation of a reinforced ovine biologic: a comparative study to available hernia mesh repair materials. Hernia, 10.1007/s10029-019-02119-z (2020) 5. S. Lun, S. M. Irvine, K. D. Johnson, N. J. Fisher, E. W. Floden, L. Negron, S. G. Dempsey, R. J. McLaughlin, M. Vasudevamurthy, B. R. Ward and B. C. May: A functional extracellular matrix biomaterial derived from ovine forestomach. Biomaterials, 31(16), 4517-29 (2010) doi:10.1016/j.biomaterials.2010.02.025 6. S. G. Dempsey, C. H. Miller, R. C. Hill, K. C. Hansen and B. C. H. May: Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix. J Proteome Res, 18(4), 1657-1668 (2019) doi:10.1021/acs.jproteome.8b00908 7. Smith MJ, Dempsey SG, Veale RW, et al. Further structural characterization of ovine forestomach matrix and multi-layered extracellular matrix composites for soft tissue repair. Journal of Biomaterials Applications. 2022;36(6):996-1010. doi:10.1177/08853282211045770 8. N. S. Greaves, S. A. Lqbal, J. Morris, B. Benatar, T. Alonso-Rasgado, M. Baguneid and A. Bayat: Acute cutaneous wounds treated with human decellularised dermis show enhanced angiogenesis during healing. PLoS One, 10(1), e0113209 (2015) doi:10.1371/journal.pone.0113209